Generic versions may still be available. Prochlorperazine (Compazine®) can be taken on a scheduled basis to prevent nausea and vomiting before chemotherapy, or can be given on an as needed basis to treat nausea or vomiting when they occur. Phenergan (promethazine) is much better tolerated by most people Compazine® Prochlorperazine Suppositories USP, 25mg (for adults) are easy to open, and available in boxes of 12. They should be avoided. Its chemical name is 2-chloro-10-[3-(4-10 methyl-1-piperazinyl)propyl]-10H-phenothiazine (Z)-2. Injectable promethazine is a possible alternative to prochlorperazine for the prevention and treatment of nausea and vomiting (Tables 1 and 2 provides a summary of additional potential alternatives).[4,5] However, severe tissue injury in the event of perivascular extravasation, intraneuronal or perineuronal infiltration, or inadvertent intra-arterial administration is possible with. Compazine vs zofran. Dronca, Charles Loprinzi, in Management of Cancer in the Older Patient, 2012. Although several theories have been proposed, the exact compazine phenergan cause remains. Drug-induced acute dystonic reactions are a common presentation to the emergency department. Formulated with phenol, promethazine has a pH between 4 and 5.5 P roblem: Promethazine (Phenergan, Wyeth) is a commonly used injectable product that possesses antihistamine, sedative, anti-motion sickness, and anti-emetic effects.The drug is also a known vesicant that is highly caustic to the intima of blood vessels and surrounding tissue. Promethazine for Acute Nausea and Vomiting Abstract & Commentary. Description and Brand Names. Compazine with prozac Promethazine is a first-generation antihistamine of the 'phenothiazine' classification often prescribed for the treatment of postoperative nausea, vomiting, and motion sickness. Dofetilide/Prochlorperazine Interactions. It may prevent you from eating, drinking, and other daily activities and can lead to weight loss,. Compazine; Compro; Mellaril; Permitil; Phenadoz; Prolixin; Serentil; Sparine. This study was conducted to compare the efficacy of prochlorperazine versus promethazine for uncomplicated nausea and vomiting in the ED. Author information: (1)Department of Emergency Medicine, Naval Hospital, Okinawa, Japan. Compazine rated 2.4/10 vs Phenergan rated 7.8/10 in overall patient satisfaction Phenergan should not be given to a child younger than 2 years old. 0. Introduction. Find out what health conditions may be a health risk when taken with Compazine Oral. Drug information provided by: IBM Micromedex US Brand Name. promethazine for headache treatment in the emergency department: a randomized controlled trial. benefit in any pregnant patient.